Monday, February 22, 2016

Cellular, Organ and Organism Level Network Resilience

This article explores the importance of a system resilience in maintaining health and function.

The cell is a network.  The body is a network.  The cell, organ and organism must have similar systems of resilience.

Conceptually every system has an accelerator and a braking system to remain stable.  

Dysfunction precedes loss.  

That is why resilience systems are vital.  BDNF and HRV heart rate variability are likely at the core of resilience.  They decline and predict system failure in cells, organs and organisms.
A midlife sympathetic tone dysfunction precedes cognitive, mood and body decline by 20 years.  Those who delay this decline maintain memory, mood and metabolism or system resilience.

We do not know what the limits of these hormetic or resilience actions, but they are substantial and worth participating in a healthy lifestyle.

HRV is proxy for this resilience.  I plan to measure my resting heart rate variability with a a $50 Bluetooth heart rate monitor and IPad app to calculate.  I hope to be able to demonstrate that lifestyle efforts to raise BDNF will increase HRV and by extension resilience and health; improved memory, mood and metabolism; reduced mortality.

The Trajectory of Life.  Decreasing Physiological Network Complexity Through Changing Fractal Patterns.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451341/pdf/fphys-06-00169.pdf



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