Acquired resilience effects every level of life from mitochondria, nucleus, cell, tissue, organ and organism.
The resilient organism has high HRV (relative to age and power)
The hormetically stressed (and resilient) organism has higher HRV for age.
This leads to an obvious paradox of organism resilience and organ damage coexisting.
In other words, high HRV AND immune stress disease aka aging.
Obviously resilience declines with aging.
Immune stress increases with age.
The paradox mentioned above is a phase equilibrium state like water and ice coexisting at 32° in the same body (of water/ice.) Safi Bahcall in Loonshots...
Protection is one side of resilience.
Power is the other side of resilience.
It is counterintuitive that adult dynamic equilibrium HRV is lower than the protection predominant state as in healthy youth but also higher than power deficit state of healthy aging.
HRV is relative and not absolute meaning that the savings rate does not imply absolute wealth but relative wealth to salary (power.).
Therefore absolute health is a function of power over (protection relative to power-HRV), and each is compounded to the apogee. How can one stay longer at the apogee level of absolute power and relative Resilience/HRV.
Who is dominant or optimum in performance, adolescents, young adults or geriatric adults?. This is the counterintuitive Goldilocks and HRV relationship. It also fits the paradigm of six sigma mean and upper and lower control limits as OUTLIERS.
One is an outlier of protection (youth) and one is an outlier of decreased power (aged.)
I have recently embarked on increasing power as an aging adult by taking niccotinamide riboside (NR.)to increase ATP production. Previously I was increasing protection by addition of Nrf2 activators to increase antioxidant enzyme capacity, and cell healing with methionine components. Both of these later components when deficient reduced further power in a negative feedback loop as measured by inflammatory biomarkers associated with aging as reported in unpublished trials.
Adding NAD precursor increased power and reduced aging inflammatory biomarkers transiently in human trials.
By addressing and restoring protection relative to power, 13 individuals have now continued to show steadily reducing inflammatory biomarkers or reversing aging.
Why was restoring protection necessary to increasing power in aged individuals?
One cannot increase power relative to the apogee of young adulthood without maintaining dynamic equilibrium with protection (and repair) forces.
HRV at peak physical, emotional and social age is the Goldilocks equilibrium of healthy adults.
In 50 year old humans NAD is 50% lower than apogee or peak.
In 50 year old humans Melatonin is likely 50% lower than apogee.
Age 50 has decreased power and protection relative to apogee or peak.
Picture the adolescent where protection is greater than power when rising to apogee or peak. HRV high.
Picture the aged where that protection is lesser than power when declining secondary to aging. HRV low.
Therefore the dynamic equilibrium state is peak power with adequate protection say age 25-35.
HRV is intermediate HRV 62 down from 68% at age 16-25.
HRV ultimately measures tone and capacity of sympathetic and vagal reserves in the locus ceruleus of the brain stem. The reserves are a function of stored fast acting chemicals and slow adding peptides.
Developmentally, the brain uses the most power as it develops and preserves a large and functioning network. Adult muscular peak lean body mass also adds power use. This is the apogee or peak mental, physical and emotional.
One might say that each system is peaking, but what about their tuning or alignment?
If our capacity to love is powerful, but the mind and bodily desires are driving without soulful controllers we are not adding both harmony and innovation.
It is this last dynamic equilibrium state that matters. Morality allows freedom, immorality ensures captivity. The rigidity of stability (homeostasis) must coexist with the flexibility of new strategies and products to drive productivity (power) safely (protection) to more and better for Mercy's and Goodness's sake. This results in more Wealth and Health as a function of time. A truly rich life requires a mission or raison d'etre.
Acquired Resilience: An Evolved System of Tissue Protection in Mammals
This review brings together observations on the stress-induced regulation of resilience mechanisms in body tissues. It is argued that the stresses that induce tissue resilience in mammals arise from everyday sources: sunlight, food, lack of food, hypoxia and physical stresses. At low levels, these stresses induce an organised protective response in probably all tissues; and, at some higher level, cause tissue destruction. This pattern of response to stress is well known to toxicologists, who have termed it hormesis. The phenotypes of resilience are diverse and reports of stress-induced resilience are to be found in journals of neuroscience, sports medicine, cancer, healthy ageing, dementia, parkinsonism, ophthalmology and more. This diversity makes the proposing of a general concept of induced resilience a significant task, which this review attempts. We suggest that a system of stress-induced tissue resilience has evolved to enhance the survival of animals. By analogy with acquired immunity, we term this system ‘acquired resilience’. Evidence is reviewed that acquired resilience, like acquired immunity, fades with age. This fading is, we suggest, a major component of ageing. Understanding of acquired resilience may, we argue, open pathways for the maintenance of good health in the later decades of human life.
Joseph Thomas (Tony) Liverman, Jr.