Monday, November 16, 2015

Overview on Importance of Metabolic Cellular Health

Overview of Metabolic Cellular Health

Machines require energy.  Biological entities require energy. Cells require energy.

Organisms degrade because organs degrade because cells degrade because their metabolic energy and substrate needs are not met because their mitochondria are degraded by inflamaging or injury.

Can this be avoided or reversed?  Consider "immortal" cell cultures of human cells and the variable length of life of various mammals as evidence that cellular life and organism life can be enhanced.

All energy comes from the sun and its energy dividends for the "circle of life" on earth.

Spiritual wisdom summarizes the known why, how and what of life  in human thought.  By this I mean to use common frames of Christian scripture to reframe the above biology!

Consider the following scriptures:

Jesus stated in John 10:10, " My purpose is to give them a rich and satisfying life...I came that they may have life, and may have it abundantly."

Proverbs 10:16 states "the wages of the righteous is life..."

Paul states that the "wages of sin is death..."

Consider the following equalities:

Wealth + Wages - Expenses

This formula for secondary property that is important but also can be taken away like silver and gold.

Health + BDNF (brain derived neurotrophic factor) -  Inflamaging (activated cellular innate immune activity)

This formula for primary property is more essential for life and cannot be taken away for the gain of others.

Here I see the energy and health of the cell as essential for a rich, satisfying and lengthy life for you.  More BDNF and less Inflamaging.  In the word of Mr. Miyagi, "wax on, wax off" meaning more life is the balance of more wax/life building action.

Perform activities that promote BDNF levels.
Avoid activities and substances that reduce BDNF or that yield more inflamaging than BDNF, more wax off than wax on.

Consider as adjuncts to more BDNF, anti-inflamaging strategies to avoid activation of the cellular inflamasome and its components NLRP3, Pro-interleukin 1beta and Caspase which together lead to apoptosis or programmed cell death.

Agents that inhibit the inflamasome components include Melatonin, DHA and Beta hydroxybutyrate (coconut oil or MCT oil derivative), red near infrared light.  See prior blogs for details.  Also know that medications including centrally acting ACE and ARB drugs inhibit the inflammasome and prolong life in heart failure, renal failure and cognitive decline secondary to neurodegenerative diseases.