Aging, Pneumonia, Exercise Shortness of Breath and BDNF
This article is relevant to aging, pneumonia, exercise dyspnea and BDNF.
The lifestyle changes that increase BDNF preserves diaphragm innervation and type 2 fibers required for explosive movements such as clearing the airway of secretions or aspiration. One can measure inspiratory and expiratory force, timing of cough to irritants (a proxy for aspiration). Exertional dyspnea correlates with peak inspiratory and expiratory force, inspiratory force/vital capacity ratio and 6 minute walk in COPD patients. (Shortness of breath with exercise improves with measures of strength of lung muscles to breathe in and breathe out, lung inspiratory strength to lung volume or size ratio, and the distance walked in 6 minutes in lung disease patients.)
BDNF likely improves presbyesophagous, epiglottis dysfunction and pharyngoesophageal dysphagia in the aging sarcopenic patient. I.e. Neuromuscular function and integrity. BDNF reverses aging of swallowing in patients losing muscle due to inflamaging.
The heart and respiratory muscles are crucial to human power production. Their poor performance is associated with increased IL-6 an inflammatory marker. In effect poor muscle function of the heart and lungs produces waste or exhausts like a car with a poorly functioning power plant.
Could interventions that increase BDNF increase 6 minute walk times? Reverse loss of respiratory muscle loss and function loss?
Weekly Intermittent fasting?
Resistance breathing training?
Slow paced breathing 2 minutes twice daily?
Antidepressant medications?
4 minute HIIE?
Is the diaphragm/lung or heart/circulatory system the stronger limiting factor for functional performance? Doesn't BDNF improve both and all?
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