Insulin Resistance Syndrome Drives Osteoarthritis and All Degenerative Diseases of Aging

Epigenetic change promotes osteoarthritis. (And all degenerative diseases of aging)

Drivers?

Leaky gut.

Methylation.

Histone acetylation.

Decreased Nrf2 (lack of BHB)

BHB beta hydroxybutyrate is a Nrf2 activator and histone deacetylase inhibitor.

Obesity, diabetes skewed toward osteoarthritis.

IRS is an OBESITY PROXY.

Healthy gut, keto diet, Mediterranean Nrf2 supplements should reduce osteoarthritis.

Atherosclerosis is promoted by inflammation.

Osteoarthritis is promoted by inflammation.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28020

Epigenetics in osteoarthritis: Novel spotlight - Fathollahi - - Journal of Cellular Physiology - Wiley Online Library

Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an absolute consequence of joint mechanical use (wear and tear); rather recent data demonstrate the pivotal role of inflammatory mediators in the development and progression of this disease. This multifactorial disease results from several environmental and inherited factors. Genetic cannot solely explain all the contribution share of inheritance and, this way, it is speculated that epigenetics can play a role, too. Moreover, environmental factors can induce local epigenetic changes. The epigenetic contribution to OA pathogenesis occurs at all of its levels, DNA methylation, histone modification, microRNA, and long noncoding RNA. In fact, during early phases of OA pathogenesis, environmental factors employ epigenetic mechanisms to provide a positive feedback for the OA‐related pathogenic mechanisms and pathways with an ultimate outcome of a well‐established clinical OA. These epigenetic changes stay during clinical disease and prevent the body natural healing and regenerative processes to work properly, resulting in an incurable disease condition. In this review article, we aimed to have an overview on the studies performed with regard to understanding the role of epigenetics in the etiopathogenesis of OA and highlighted the importance of such kind of regulatory mechanisms within this context.

Joseph Thomas (Tony) Liverman, Jr.