Melatonin reduces oxidative stress that crosstalks with the other factors of ovarian aging.
Ovaries (and testes) age in advance of the organism.
Therefore, what slows gonadal aging SLOWS ALL AGING.
Interestingly, PCOS polycystic ovarian system (4% of women) is associated with both premature ovarian aging and insulin resistance syndrome.
INSULIN RESISTANCE SYNDROME is the root cause of DEGENERATIVE OXIDATIVE AUTOIMMUNE DISEASES.
Insulin resistance is the root cause of oxidative stress and premature aging.
Calorie restriction (fat consumption for energy) reverses many of the listed factors of ovarian (organisms) aging.
Why?
Clean burning triglyceride reduces oxidative stress and improves the other listed aging factors below.
Fasting is cleaner than ketodiet.
Ketodiet is cleaner than western diet.
Western diet with (nrf2 activators, molecular hydrogen, magnesium and spermidine-wheat germ) is cleaner than western diet sans supplement.
Sulforaphane (nrf2 driver) and Spermidine in yeast, C elegans worms, fruit flies, mice and human cell cultures prolong healthspan and lifespan (slow aging).
The lean athletic individual on ketodiet, melatonin, nrf2 activators, molecular hydrogen, magnesium and spermidine-wheat germ MAY SLOW AGING.
A proxy test for this hypothesis is delayed menopause and delayed andropause in the intermediate term.
A short term proof might be restoring fertility in PCOS.
Ketodiet in PCOS associated infertility reverses insulin resistance syndrome and improves fertility rates.
Melatonin also reverses insulin resistance syndrome effects and improves fertility rates.
Melatonin as Potential Targets for Delaying Ovarian Aging: Ingenta Connect
In previous studies, oxidative stress damage has been solely considered to be the mechanism of ovarian aging, and several antioxidants have been used to delay ovarian aging. But recently, more reports have found that endoplasmic reticulum stress, autophagy, sirtuins, mitochondrial dysfunction, telomeres, gene mutation, premature ovarian failure, and polycystic ovary syndrome are all closely related to ovarian aging, and these factors all interact with oxidative stress. These novel insights on ovarian aging are summarized in this review. Furthermore, as a pleiotropic molecule, melatonin is an important antioxidant and used as drugs for several diseases treatment. Melatonin regulates not only oxidative stress, but also the various molecules, and normal and pathological processes interact with ovarian functions and aging. Hence, the mechanism of ovarian aging and the extensive role of melatonin in the ovarian aging process are described herein. This systematic review supply new insights into ovarian aging and the use of melatonin to delay its onset, further supply a novel drug of melatonin for ovarian aging treatment.
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