Long telomeres and increased antioxidant capacity is associated with longevity.
Here they are directly proportional and reflect RESILIENCE.
Telomeres are lengthened by telomerase.
Telomerase can only enter the nuclear pore when the cytoplasm is not under oxidative stress. When there is adequate antioxidant capacity- superoxide dismutase and glutathione telomeres can be repaired.
One can use relative telomere length as a proxy for innate resilience.
I hypothesis that telomere length is directly proportional to HRV index and predicts children who maintain their synaptic connections or brain network which is a predictor for higher IQ, higher income etc.
We likely can improve educational and intellectual success by improving resilience.
Resilience can be predicted by HRV index.
Resilience and brain network preservation is greater than pedagogy for maxims educational attainment.
Nuclear DNA integrity and mitochondrial DNA integrity is therefore permissive when adequate antioxidant capacity and proteostasis is high.
Proteostasis is a function of spermidine.
This blog is aligned with longevity which is directly proportional to RESILIENCE.
This study in mice also explores the resilience of siblings raised in the same environment and discovered resilience is a function of oxidative capacity and telomerase.
Telomere length, sibling competition and development of antioxidant defense in wild house mice
Antioxidants and telomere length are potential biomarkers for individuals’ exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house mice in a longitudinal study with natural sibling competition as a stressor. Blood was used for telomere length measurements at 8-weeks age and for several selected antioxidants at 8-weeks and 6-months age. Our results show that most of the antioxidants increase during that time, indicating that antioxidant-system continues to develop after early development and sexual maturation. In addition females had higher antioxidant-levels than males. Mice with longer telomeres had also higher superoxide dismutase-activity and more glutathione than mice with shorter telomeres, meaning that long telomeres are associated with better antioxidant defense at maturation and during later life. Sibling competition at early age affected superoxide dismutase-levels at 6-months, but only in females. Females, which were lighter than the average of the litter had low superoxide dismutase –activity in later adulthood, indicating delayed negative effect of sibling competition on antioxidant defense. Our results highlight that sex and developmental stage are crucial in intraspecific comparisons of the antioxidant status and its alterations
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