Melatonin is an exercise mimetic.
Melatonin increases insulin sensitivity.
Melatonin increases Sirt1.
Sirt1 is a nutrient sensor BUT it also rises with melatonin.
Melatonin increases mitochondrial biogenesis, the volume of cellular mitochondria.
Nutrient sensing must signal relative to mitochondria volume.
Melatonin effects on metabolic signaling may be relative to mitochondrial volume.
Age and disease decrease melatonin.
The sickest persons due to metabolic syndrome, aka endothelial dysfunction, improve the most with calorie restriction indicating that "relative" melatonin, relative Sirt1 to mitochondrial volume improves flow mediated dilation or endothelial function.
Melatonin declines with aging.
Melatonin is high in nuts and olives oil.
Meat rich diet plus one oz of nuts reduce CAD coronary artery disease odds ratio from 1.6 to O.6.
Melatonin concentrates in mitochondria.
The DASH and Mediterranean diet lower blood pressure 10-14 points.
Is this due to melatonin, Sirt1 or Nrf2 activation which follows either melatonin or Sirt1 increases.
Increasing relative melatonin/sirt-1/mitochondrial volume improves health and longevity.
Persons with high levels of Sirt1 have proved increased longevity.
Higher Sirt1 due to gene polymorphism AND/OR calorie restriction, exercise and exercise mimetics.
Heat is an exercise mimetic, sauna, steam or immersion.
Caloric Restriction and Its Effect on Blood Pressure, Heart Rate Variability and Arterial Stiffness and Dilatation: A Review of the Evidence
Abstract
Essential hypertension, fast heart rate, low heart rate variability, sympathetic nervous system dominance over parasympathetic, arterial stiffness, endothelial dysfunction and poor flow-mediated arterial dilatation are all associated with cardiovascular mortality and morbidity. This review of randomised controlled trials and other studies demonstrates that caloric restriction (CR) is capable of significantly improving all these parameters, normalising blood pressure (BP) and allowing patients to discontinue antihypertensive medication, while never becoming hypotensive. CR appears to be effective regardless of age, gender, ethnicity, weight, body mass index (BMI) or a diagnosis of metabolic syndrome or type 2 diabetes, but the greatest benefit is usually observed in the sickest subjects and BP may continue to improve during the refeeding period. Exercise enhances the effects of CR only in hypertensive subjects. There is as yet no consensus on the mechanism of effect of CR and it may be multifactorial. Several studies have suggested that improvement in BP is related to improvement in insulin sensitivity, as well as increased nitric oxide production through improved endothelial function. In addition, CR is known to induce SIRT1, a nutrient sensor, which is linked to a number of beneficial effects in the body. View Full-Text
Joseph Thomas (Tony) Liverman, Jr.
No comments:
Post a Comment