Melatonin appears to be permissive for increased fat metabolism, especially visceral body fat. This appears to be associated with increased Irisin.
Ursolic acid increases Irisin and has increased triglyceride metabolism.
Perhaps Ursolic acid during wake/feeding time and Melatonin during sleep/fasting time promotes both growth and recovery simultaneously with variable calorie burn. Stored fat may be unfinished business of growth and incomplete recovery in an adjustable just in time metabolism!
I conjecture that the thrifty phenotype that cannot lose weight without excessive privation has "unfinished business" because they are simultaneously trying to perform growth and recovery at the same time due to mixed signaling.
One way to clarify metabolic signaling for clock genes is a prolonged fast period. Therefore a restricted feeding cycle of 4-8 hours and a fasting cycle of 16-20 hours would restore "go slow complete your task functioning" would be beneficial to badly disrupted metabolic health. Weekly intermittent fasting may be sufficient for milder disruptions.
Effects of melatonin on lipid metabolism and circulating irisin in diet-induced obese Sprague-Dawley rats
+ Author Affiliations
Globesity refers to the worldwide increase of excess weight and obesity according to World Health Organization. Previous studies indicated melatonin, master clock controlling circadian rhythm, may halt body weight gain by increasing recruitment of brown adipose tissues. In light of the pressing need to check the progression of obesity, our study was aimed at investigating effects of oral melatonin administration on body fat accumulation and lipid parameters. Especially, we analyzed irisin, a novel myokine associated with browning effect of white adipose tissues, as the biomarker of brite/beige adipocytes. Forty 8-wk-old male Sprague-Dawley rats were divided into 5 groups: vehicle control (VC), positive control (PC), MEL10 (10 mg melatonin/kg BW), MEL20 (20 mg melatonin/kg BW) and MEL50 (50 mg melatonin/kg BW). Vehicle control group was fed control diet, and the other groups were fed high fat and high calorie diet for 6 weeks before melatonin treatment to induce obesity. Melatonin was dissolved in ethanol and diluted in drinking water with aluminum foil covering water bottle. Rats were treated for 8 weeks and sacrificed. We found that there is no deference in food and water intake, and melatonin administration can halt body weight gain, decrease accumulation and distribution of white adipose tissues, increase brown adipose tissue and brite/beige adipocytes, and lipid parameters were improved. Serum irisin concentration was significantly increased in melatonin-treated groups.
No comments:
Post a Comment