Subjects:. Smokers without cardiovascular morbidities less than 50 years of age.
Methods:. Apply refrigerated cold pack to upper two thirds of face for 120 seconds while bending forward to produce mild valsalva maneuver and breathing in 5 seconds and out for 5 seconds for the 120 seconds. Perform at least twice daily and add lib if urge to smoke.
Endpoint:. Complete Smoking cessation for 6 weeks. Follow up for 3-6 months.
Rationale and discussion.
Vagal exhaustion or reduced vagal tone is associated with autonomic symptoms of depression, hopelessness, anxiety, poor concentration, appetite change and sleep change.
All these symptoms are subjectively improved by smoking and worsened by nicotine withdrawal.
Nicotine activates the Nicotinic acetylcholine receptor.
Chantix activates a subtype of Nicotinic receptor where it's binding produces agonist activity, while simultaneously preventing nicotine binding to alpha 4 beta 2 receptor.
Nicotine and chantix activate a cholinergic receptor to either maintain smoking benefits or taper off.
A more enduring taper and maintenance program would therefore activate the cholinergic peripheral receptors independent of nicotine or chantix.
The diving reflex activates the cholinergic anti inflammatory pathway peripherally and restores vagal tone.
The cholinergic anti inflammatory pathway corrects autonomic symptoms of depression, hopelessness, anxiety, poor concentration, appetite change and sleep change.
Therefore a healthy and effective substitute is available that restores resilience into recovery by restoring autonomic vagal nerve tone that makes one resilient to ADDICTIONS.
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