Here below explained is that toxic mitochondria signals the sterile inflammation characteristic of autoimmune disease and aging.
Autophagy (cell recycling) and Mitophagy (mitochondrial recycling or replacement) reduce the inflamasome initiator, NLRP3 the innate cell immune system, activation by their triggers.
It is a reasonable assumption that factors that increase those recycling processes reduce the degree of autoimmune disease.
12 hours of daily fasting. Autophagy.
24 hours of weekly fasting. Mitophagy.
Melatonin 3-6 mgs at night. Autophagy and antioxidant.
DHA 1000 mgs daily. Inhibits Il B a component of activated inflamasome.
Ursolic acid 200 mgs 1-3 times daily promotes metabolism of toxic LPS and promotes fatty acid metabolism and production of beta hydroxybutyrate which promotes the transcription of 44 starvation gene set proteins that repair the cell.
Ubiquinol 100 mgs. Improves mitochondria.
PQQ 20mgs. Promotes mitochondrial biogenesis and lowers ROS production, a toxic side effect of mitochondrial oxidative phosphorylation.
The key idea above is that beta hydroxybutyrate,a ketone, promotes repair inclusive of autophagy Mitophagy and their gene initiators expression.
This improves age related inflamaging and autoimmune diseases like PSS, RA etc.
This is the same set of therapeutic interventions that Dr. Dale Bredson used to reverse dementia in 9 of 10 apoE positive patients with cognitive decline!
http://www.clinexprheumatol.org/article.asp?a=10865
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