Healthy Longevity Depends on Mitochondrial Fitness and Number

Interesting article below with the following implications.

Timed eating less than half the day allows for recovery and adaptation of mitochondria in the fasting half of the day preventing mitochondrial exhaustion.

Mitochondria numbers are increased by biogenesis and decreased by inflamaging.

More biogenesis means more mitochondria and less stress per mitochondria, therefore exercise, fasting, MCT oil and Ursolic acid promotion of increased mitochondria is better for health.

Decreased inflamaging through melatonin, Dha, COq10 and PQQ etc promotes recovery from metabolic stress and is better for health.

More mitochondria and less stress per mitochondria equals health and longevity.

Just another way to state that health equals autophagy,mitophagy minus inflammasome.

See example physician patient video below as example.

See Minding your mitochondria Dr. Terry Wahls at Ted.com as validation of this concept.  She did not document her calorie restriction or her time of fasting but this can be derived from her diet.

This disabled multiple sclerosis patient fully recovered with perfect nutrition targeting inflamaging and avoiding over nutrition and promoting mitochondrial rich nutrition.  She recovered from bed rest and moterized wheelchair to biking and horseback riding over the course of one year.

I am less motivated and , I believe, more resilient at baseline than the resourceful and recovered MS physician/patient who healed her mitochondria in order to reverse MS changes, and I strive to do the following:

Fast 12 hours per day.

Fast 24 hours per week.

Exercise.

Slow paced breathing twice daily.

Ursolic acid.

Melatonin.

DHA.

B complex vitamins.  Because I, like 30% of persons, am MTHFR heterozygous (from gene testing) I augment with L-methyl folate, methylB12 and Activated B6.

Highlights

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  Time-controlled fasting improves mitochondrial metabolism of fat cells.
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  Mitochondrial flexibility maintains adipose tissue functionality.
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  Transient ^mtROS flux, FoxO1 and AMPK promote healthy aging.

http://www.sciencedirect.com/science/article/pii/S1568163716300861

Feast and famine: Adipose tissue adaptations for healthy aging

Abstract

Proper adipose tissue function controls energy balance with favourable effects on metabolic health and longevity. The molecular and metabolic asset of adipose tissue quickly and dynamically readapts in response to nutrient fluctuations. Once delivered into cells, nutrients are managed by mitochondria that represent a key bioenergetics node. A persistent nutrient overload generates mitochondrial exhaustion and uncontrolled reactive oxygen species (^mtROS) production. In adipocytes, metabolic/molecular reorganization is triggered culminating in the acquirement of a hypertrophic and hypersecretory phenotype that accelerates aging. Conversely, dietary regimens such as caloric restriction or time-controlled fasting endorse mitochondrial functionality and ^mtROS-mediated signalling, thus promoting geroprotection. In this perspective view, we argued some important molecular and metabolic aspects related to adipocyte response to nutrient stress. Finally we delineated hypothetical routes by which molecularly and metabolically readapted adipose tissue promotes healthy aging.

Joseph Thomas (Tony) Liverman, Jr.