Micro needling the skin to a depth of 0.5 mm improves regeneration of skin and reduced aging of skin to a depth of 12 mm due to signalling and increasing growth and regenerative peptides.
Knees undergoing sham arthroscopy improved equal to "clean out" procedures.
Knee synvisc injections divided into 5 shots were better than 3 shots were better than 1 shot.
Red Near infrared laser light improved joint pain by signalling growth and regeneration.
Red Near infrared laser light treatment of leg bone marrow activated adult mesenchymal stem cells to travel and relocated to injured brain where they attracted growth and regenerative peptides including BDNF.
The concept is clear that growth and regenerative peptides can be increased and work through a variety of signaling mechanisms.
One should not have to needle the hippocampus to signal. Transcranial direct current, transcranial magnetic stimulation, red near infrared light stimulation or deep brain electrical stimulators would probably all work!
http://www.kurzweilai.net/micro-needle-insertion-into-hippocampus-helps-brain-regeneration-in-animal-model-of-ad
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