The Downstream Targets of Complex I Dysfunction in Bipolar Disorder
This article is supplementary to the adolescent monocyte macrophage inflammatory findings in progeny of a bipolar parent in advance of expressed disease. Complex 1 is one of 5 complexes in the mitochondrial electron transport chain that produces ATP or cellular energy.
To wit, in this article older bipolar patients are inflamed and specifically show dysfunction in Complex 1, the downstream target of inflammatory damage to mitochondrial energy production.
Ubiquinol the reduced form of CoQ10, specifically is involved in complex 1 and is an antioxidant in the cytosol that reduces reactive oxygen species that trigger the inflamasome. Melatonin is a cytosol AND mitochondrial ( a transcellular) antioxidant that might prevent the activation of adolescent immune macrophage cells that are at risk of neuroinflammatory changes.
Conjecture: Macrophage cells in the brain otherwise named microglial cells become inflamed and activate the systemic and innate immune system of neurons and their energy producing mitochondria.
Conjecture: Manifest bipolar disease treatment should target Complex 1 with Ubiquinol in addition to Melatonin supplementation to reduce neuroinflammation.
Conjecture: Adolescents with a bipolar parent should reduce monocyte macrophage and microglial inflammation by nightly Melatonin supplementation. They should also follow a Mediterranean diet which is inherently higher with dietary sources of Melatonin.
Melatonin is a safe and harmless supplement which may or may not prevent the "downstream targets of complex 1 dysfunction in bipolar disorder."
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