Adolescents with bipolar lineage have decreased BDNF and increased inflammasome activity.

Adolescents with bipolar lineage have decreased BDNF and increased inflammasome activity.  

Can one prevent and or improve bipolar onset or symptoms in susceptible or diagnosed individuals?  

BDNF is normal in bipolar individuals without symptoms but decreased in both depressed and manic states.

Bipolar has 1% lifetime prevalence.  Depression has 6% prevalence.

How to treat follows:

DHA and Melatonin reduces brain Inflammasome activity.  Slow paced breathing reduces brain TNF alpha and cortisol.

1.  DHA. 1000 mgs daily.

2.  Melatonin 3 mgs at evening.

3.  Shoulders level throughout belly breathing 5 seconds in 5 seconds out for 2 minutes twice daily.

Intermittent fasting, high intensity interval exercise, slow paced breathing and brain.hq.com increases neuroprotective BDNF.

1.  See beginning of blog.

I believe from this evidence below that Bipolar and other mood disorders can be prevented or countered by the same treatments for prevention of Alzheimer's and Parkinson's; 1. increasing BDNF and 2. inhibiting the inflammasome especially of glial and macrophage cells which are the bridge between cellular innate immunity and the systemic immune system.

This bipolar disease prevention strategy is analogous to diabetes prevention strategy via exercise and diet.  

The link below has abstract and full text.

http://onlinelibrary.wiley.com/doi/10.1111/bdi.12231/full

Joseph Thomas (Tony) Liverman, Jr.