This article was sent to me stating that melatonin prevented or cured an animal model of pulmonary artery hypertension.
Melatonin as preventative and curative therapy in pulmonary hypertension.
This is a provocative abstract. I had also previously reviewed other various animal models of inducing pulmonary artery hypertension and cardiomyopathy. (Resulting in thickened, fibrosed blood vessels, heart and lung interstiums with decreased compliance or elasticity.). Incidentally this also describes changes occurring with skin aging.
To wit. The fibrosis, inflammation and pulmonary artery hypertension is due to pressure and degenerative changes via the inflamasome mechanism. Melatonin blocks the increase in oxygen radicals that activate the inflamasome cascade of caspase and Il-1B.
Melatonin can be given ahead or at the time of ischemia-reperfusion and acts via blocking the inflamasome.
This same inflamasome causes pyroptosis or cellular degradation leading to disruption of cellular calcium potassium channels and mitochondrial integrity with further activation of the inflamasome. Without energy or capital, cells degrade, fibrose or die.
This is the fate of pancreatic beta cells and alpha cells. Inflamasome activation and mitochondrial pyroptosis leading to energy poor cells and little or no production of glucagon or insulin.
Broadly speaking, there are studies supporting four methods to block the inflamasome.
1. DHA 1000 mgs daily.
2. Melatonin 3-6 mgs in evening.
3. MCT oil or coconut oil 30 mls daily blended in food or liquid.
4. Red Near Infrared light absorbed by cytochrome c in mitochondria yielding additional infusion of ATP for cell energy and cell capital. More on this in my next blog post.
The core defect of metabolic syndrome is decreased fatty acid oxidation leading to greater reliance on glucose metabolism and net loss of peak cellular energy. A cell or business bleeding energy, cash or capital will become weak.
BDNF is a bio marker for efficient fatty acid oxidation and metabolic health.
When BDNF is elevated by lifestyle, diet and brain fitness, cells have abundant energy with strong reserves in stored body fat for the body and glucose and ketones for the brain.
Experiment: treat metabolic syndrome patients with Mediterranean diet, intermittent weekly fasting, HIIE 4 minutes daily, Weekly resistance training, Brain speed training to restore BDNF levels and fatty acid oxidation. With and without the 4 blocking the inflamasome measures above. Return to normal? Reversed metabolic syndrome?
An inverse study variation of the above would be to inversely treat metabolic healthy persons and give a high carb diet, little or no exercise, no computer access no socialization.
Prisoners? Trauma victims? Open heart surgery patients? Stroke patients? BDNF should go down, energy down, apathy up, cognitive slowing ( all symptoms of depression) and increased inflammatory markers up as the inflamasome is not inhibited. Expect increase numbers of Metabolic syndrome markers with inflammation markers up.
Joseph Thomas (Tony) Liverman, Jr. MD
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