Alzheimer's Review Article Prescription for Action.

Brain metabolic health and Body metabolic health are linked through shared metabolism, inflammation and repair pathways.  

Therefore improving the metabolism of the body or brain helps both.  

Inhibiting the inflamasome cascade helps both brain and body.  

Promoting the repair and longevity gene expression in brain and body cells builds resilience for both.  

What would supply evidence of increased physical resilience?

A body with increased aerobic capacity for exercise?

A body with increased lean body mass?

A body that metabolizes fat into ketones after an overnight 10 hour fast?

Increased beat to beat heart rate variability?

More good HDL cholesterol?

Less bad LDL cholesterol?

LDL cholesterol particles that are larger, with lower particle count and hence are less atherogenic?

Increased BDNF, GDNF and NGF?

Increased insulin sensitivity?

Increased sympathetic, parasympathetic tone?

Increased subcortical and cortical brain speed for auditory and visual processing speed?

ALL the above RESULT FROM THE FOLLOWING PRESCRIPTION that increases BDNF.

1. Mediterranean diet with supplemental MCT and coconut oil. 30 ml once daily for low dose and up to 4 doses daily for high dose.

2.  HIIE 4 minutes daily 5 or more days per week.  Resistance training once per week (low dose) or 3-5 times per week (high dose)

3.  Brain training up to 40 hours or 90 percentile.  Note that subcortical sensory processing is the most improved part of the brain, the automatic non thinking part of responding to brain exercises. Alzheimer's is believed to begin in the brain stem and degrade noradrenergic neurons antegrade to the higher cortex.

4.  2 minutes of slow paced breathing 5 secs in and 5 secs out for two minutes twice daily.

5.  VLS#3 a commercial probiotic has recently been shown in mice to reduce inflammation in the brain by its effect on modulating the gut-brain axis and increasing BDNF either directly or indirectly by inhibiting micro glia action in the brain.  These bacteria may increase short chained fatty acids in the gut from unrestricted starch such as the fiber of nuts.